Mild Parkinsonian signs are associated with lower olfactory test scores in the community‐dwelling elderly
Identifieur interne : 002766 ( Main/Exploration ); précédent : 002765; suivant : 002767Mild Parkinsonian signs are associated with lower olfactory test scores in the community‐dwelling elderly
Auteurs : Elan D. Louis [États-Unis] ; Karen Marder [États-Unis] ; Matthias H. Tabert [États-Unis] ; Devangere P. Devanand [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-03-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Personne âgée.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Dementia (diagnosis), Dementia (epidemiology), Diagnosis, Differential, Elderly, Epidemiology, Female, Follow-Up Studies, Humans, Male, Movement Disorders (diagnosis), Movement Disorders (epidemiology), Nervous system diseases, Olfaction, Olfaction Disorders (diagnosis), Olfaction Disorders (epidemiology), Parkinson disease, Parkinsonian Disorders (diagnosis), Parkinsonian Disorders (physiopathology), Prevalence, Residence Characteristics, Score test, Severity of Illness Index, Sign, elderly, epidemiology, mild parkinsonian signs, olfaction, population.
- MESH :
- diagnosis : Dementia, Movement Disorders, Olfaction Disorders, Parkinsonian Disorders.
- epidemiology : Dementia, Movement Disorders, Olfaction Disorders.
- physiopathology : Parkinsonian Disorders.
- Aged, Aged, 80 and over, Diagnosis, Differential, Female, Follow-Up Studies, Humans, Male, Prevalence, Residence Characteristics, Severity of Illness Index.
Abstract
Mild Parkinsonian signs (MPS, impaired gait, rigidity, bradykinesia, rest tremor) are commonly found during the clinical examination of older people and may be a precursor to Parkinson's disease (PD) or Alzheimer's disease (AD). Marked deficits in olfaction occur in PD and AD. The objective of this study was to determine whether University of Pennsylvania Smell Test (UPSIT) scores were lower in nondemented community‐dwelling elderly with versus without MPS. Nondemented persons age ≥65 years without PD in Washington Heights‐Inwood, NY were evaluated with an abbreviated motor Unified PD Rating Scale and a 40‐item UPSIT. Lower UPSIT and higher transformed UPSIT score (square root [UPSIT ‐ 41]) indicated greater olfactory dysfunction. One‐hundred‐seventy‐seven (16.4%) of 1,078 participants had MPS. Mean UPSIT scores (MPS vs. without MPS) were 24.3 ± 7.1 versus 26.4 ± 6.8, P < 0.001. In a logistic regression analysis adjusting for age and education, transformed UPSIT score was associated with MPS (OR 1.25, 95% CI 1.04–1.52, P = 0.02). In an adjusted logistic regression analysis, participants with higher transformed UPSIT scores (based on a median split) were 1.55 times more likely to have MPS than were those with lower scores (P = 0.01). Within transformed UPSIT score quartiles, the odds of having MPS were 1.0 (reference), 1.35, 2.02, and 2.20 (P < 0.05). The association with transformed UPSIT scores was similar across MPS subtypes (axial dysfunction, rigidity, tremor).MPS were associated with a mild reduction in olfactory function. These observations further support the view of MPS as a marker of emerging degenerative brain pathologies. © 2007 Movement Disorder Society
Url:
- https://api.istex.fr/document/8E1BF07B1A55A38FA97D0A818AAF720FED8E40DD/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679986
DOI: 10.1002/mds.21777
Affiliations:
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Marked deficits in olfaction occur in PD and AD. The objective of this study was to determine whether University of Pennsylvania Smell Test (UPSIT) scores were lower in nondemented community‐dwelling elderly with versus without MPS. Nondemented persons age ≥65 years without PD in Washington Heights‐Inwood, NY were evaluated with an abbreviated motor Unified PD Rating Scale and a 40‐item UPSIT. Lower UPSIT and higher transformed UPSIT score (square root [UPSIT ‐ 41]) indicated greater olfactory dysfunction. One‐hundred‐seventy‐seven (16.4%) of 1,078 participants had MPS. Mean UPSIT scores (MPS vs. without MPS) were 24.3 ± 7.1 versus 26.4 ± 6.8, P < 0.001. In a logistic regression analysis adjusting for age and education, transformed UPSIT score was associated with MPS (OR 1.25, 95% CI 1.04–1.52, P = 0.02). In an adjusted logistic regression analysis, participants with higher transformed UPSIT scores (based on a median split) were 1.55 times more likely to have MPS than were those with lower scores (P = 0.01). Within transformed UPSIT score quartiles, the odds of having MPS were 1.0 (reference), 1.35, 2.02, and 2.20 (P < 0.05). The association with transformed UPSIT scores was similar across MPS subtypes (axial dysfunction, rigidity, tremor).MPS were associated with a mild reduction in olfactory function. These observations further support the view of MPS as a marker of emerging degenerative brain pathologies. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region><settlement><li>New York</li></settlement><orgName><li>Université Columbia</li></orgName></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name></region><name sortKey="Devanand, Devangere P" sort="Devanand, Devangere P" uniqKey="Devanand D" first="Devangere P." last="Devanand">Devangere P. Devanand</name><name sortKey="Devanand, Devangere P" sort="Devanand, Devangere P" uniqKey="Devanand D" first="Devangere P." last="Devanand">Devangere P. Devanand</name><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name><name sortKey="Marder, Karen" sort="Marder, Karen" uniqKey="Marder K" first="Karen" last="Marder">Karen Marder</name><name sortKey="Marder, Karen" sort="Marder, Karen" uniqKey="Marder K" first="Karen" last="Marder">Karen Marder</name><name sortKey="Marder, Karen" sort="Marder, Karen" uniqKey="Marder K" first="Karen" last="Marder">Karen Marder</name><name sortKey="Tabert, Matthias H" sort="Tabert, Matthias H" uniqKey="Tabert M" first="Matthias H." last="Tabert">Matthias H. Tabert</name><name sortKey="Tabert, Matthias H" sort="Tabert, Matthias H" uniqKey="Tabert M" first="Matthias H." last="Tabert">Matthias H. Tabert</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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